Research

Dr O'Kane Research PicDr O’Kane is an active researcher within cardiology with multiple articles published in many of the world’s leading medical journals, as well as several presentations at the most prestigious cardiology conferences. Click on the tabs below to explore each of these.


2012

Rawlins J, Shah N & O’Kane P
Contemporary clot busting in STEMI: beware of the thrombus
Heart doi:10.1136/heartjnl-2012-302059

Ramtohal R, George S, Ponnampura C, Radvan J, Bull R, O’Kane P
‘New World’ imaging for an ‘Old World’ disease: Use of Cardiac MRI & 3D transoesophageal echocardiography in severe rheumatic mitral valve disease
Journal of Cardiology Cases 2012
http://dx.doi.org/10.1016/j.jccase.2012.02.005

2011

Fernandez JP, Hobson AR, McKenzie D, Talwar S, O’Kane P
Excimer Laser Coronary Atherectomy: A Novel Strategy to Aid Management of Stent Underexpansion
Eurointervention 2011; 7(3): 400-407

Child N, Fernandez JP, O’Kane P
Radial artery sheath reaction treated with oral steroids
BMJ 2011; 342:d1287

McKenzie D, Talwar S, Jokhi P, O’Kane P
How should I treat severe coronary artery calcification when it is not possible to dilate a balloon or deliver a RotaWire™?
Eurointervention 2011; 6(6): 779-783

2010

Fernandez JP, Hobson AR, McKenzie D, Talwar S, O’Kane P
Treatment of calcific coronary stenosis with the use of excimer laser coronary atherectomy and rotational atherectomy
Interventional Cardiology 2010 2(6) 801-806

Jokhi P & O’Kane P
Induction of mechanical and ST-T alternans following angioplasty in severe heart failure
Eurointervention 2010; 6(1): 171

2009

O’Kane P & Redwood S
Laser for PCI (Chapter 34)
Oxford Textbook of Interventional Cardiology
Oxford University Press, 2010

Jokhi PP, McKenzie D, O’Kane P
Use of a novel pericardial covered stent to seal an iatrogenic perforation
Journal of Invasive Cardiology 2009; 21(10): E187-90

O’Kane P, Xie L, Liu Z, Queen L, Jackson G, Yong J & Ferro A.
Aspirin acetylates nitric oxide synthase type 3 in platelets thereby increasing its activity
Cardiovascular Research 2009; 83: 131-139

2008

Lockie T, Perera D, O’Kane P, Hartley S, Khan S, Webb I, Redwood S
Deferral of coronary intervention on the basis of fractional flow reserve measurement: a real-world analysis
Cardiovascular Revascularization Medicine 2008; 9 (3), 199-200

Jokhi P, Talwar S, O’Kane P
Use of laser atherectomy and IVUS guidance during PCI on a saphenous vein bypass graft with subacute total occlusion
Eurointervention 2008; 4 (Web)

O’Kane P, Reebye V, Yong J, Stratton P, Jackson G, Ferro A
Aspirin and clopidogrel treatment impair nitric oxide biosynthesis by platelets
Journal Molecular & Cellular Cardiology 2008 45; 223-229

O’Kane P, Jackson G & Ferro A.
Whole body nitric oxide production is not decreased in patients with coronary atherosclerosis but is inversely related to plasma homocysteine
Atherosclerosis: 2008; 196 574-579

2007

O’Kane P, Blows L, & Redwood S
New Devices Illustrated: The Venture Wire Control Catheter
The British Journal of Cardiology 14 (6) 293-295

2003

O’Kane P & Jackson G
Atrial fibrillation (Review)
In: M Selby (ed) Clinical General Practice, vol. 1, Ch. 9, pp 43–48.
Butterworth Heinemann, Edinburgh, 2004

2002

O’Kane P, Queen L, Stratton P, Jackson G & Ferro A.
Aspirin modifies nitric oxide synthase activity in platelets: effects of acute versus chronic aspirin treatment
Cardiovascular Research 2003; 59; 152-9

2001

O’Kane P & Jackson G.
Cardiovascular Disease in the Elderly (Review)
Chapter 13 for Cardiology: Current Perspectives, Martin Dunitz, London 2002

O’Kane P & Jackson G.
Erectile dysfunction: Is there underlying obstructive coronary artery disease?
International Journal of Clinical Practice 2001; 55(3):219-220 (80 Citations)

2000

O’Kane P & Jackson G.
Biochemical Assays in Acute Coronary Syndrome (Editorial)
Emirates Medical Journal 2000; 18(3) 173-176

O’Kane P & Jackson G.
Atrial Fibrillation: an update (Review)
Update February 2000; 241-249

O’Kane P & Jackson G.
Sexual Activity and the Cardiac Patient
Sexual Dysfunction in Medicine 2000; 1(3): 92-94

1999

O’Kane P & Jackson G.
Cardiovascular Disease in the Elderly (Review)
Practitioner 1999 Jul; 243(1600):574-80

2005

Acute Systemic Aspirin Administration Increases Basal But Suppresses Beta-2-Adrenoceptor Stimulated Forearm Blood Flow
Presented as an oral communication at the British Pharmaceutical Society Winter Conference, London, (PublishedBritish Journal of Pharmacology 2006 61(5):616)

2002

Divergent Effects of Aspirin on Basal and Beta-adrenoceptor Stimulated Nitric Oxide Synthase Activity in Platelets
Presented as an oral communication at the British Cardiac Society Annual Conference, Harrogate, UK (PublishedHeart 2002: 87(supp II) 71, 28)

Divergent Effects of Aspirin on Basal and Beta-adrenoceptor Stimulated Nitric Oxide Synthase Activity in Platelets
Presented as an oral communication at the World Congress of Cardiology, Sydney, Australia, 6th May 2002 (PublishedJACC  2002: 39(9): 2056, 13B)

Divergent Effects of Short- and Long-Term Exposure to Aspirin on Basal and Beta-adrenoceptor Stimulated Nitric Oxide Synthase Activity in Platelets
Presented as a poster communication at the American College of Cardiology Annual meeting, Atlanta, US, 18th March 2002 (PublishedJACC 2002; 39(5): 1082-76, 225A)

2001

Divergent Effects of Short- and Long-Term Exposure to Aspirin on Basal and Beta-adrenoceptor Stimulated Nitric Oxide Synthase Activity in Platelets
Presented as an oral communication at the 4th International Congress on Coronary Artery Disease, Prague, Czech Republic, 23rd October 2001
(PublishedJournal of Coronary Artery Disease 2001; 4(1), 144)

Chronic aspirin therapy inhibits activation of nitric oxide synthase by beta-adrenoceptor agonists in platelets
Presented as poster communication at the XXIII European Society of Cardiology Congress, Stockholm, Sweden, 2nd September 2001
(PublishedEuropean Heart Journal 2001; 22(Suppl), P1012)

Basal whole body nitric oxide production is similar in patients with coronary artery disease compared to healthy subjects
Presented as an oral communication at the 2nd International Congress of Heart Disease-New trends in research, diagnosis and treatment, Washington DC, US, 22nd July 2001
(PublishedJournal of Heart Disease 2001; 2(1), 127)

Activation of platelet nitric oxide synthase by beta-adrenoceptor agonists is impaired in patients with coronary artery disease
Presented as an oral communication at the 2nd International Congress of Heart Disease-New trends in research, diagnosis and treatment, Washington DC, US, 22nd July 2001
(PublishedJournal of Heart Disease 2001; 2(1), 10)

Activation of platelet nitric oxide synthase by beta-adrenoceptor agonists is impaired in patients with coronary artery disease
Presented as a poster communication at the XVIII Congress of The International Society on Thrombosis and Haemostasis, Paris, July 2001
(PublishedThrombosis and Haemostasis, 2001; Suppl., 1203)

2000

b2-adrenoceptor activation of platelet nitric oxide synthase is impaired in patients with coronary atherosclerosis
Presented as an oral communication at the Physiological Society meeting at Imperial College, London, April 2000
(PublishedJournal of Physiology 2000; 525, P14-15)

1999

Measuring Lipid Profiles During Coronary Angiography
Presented as an oral communication at the Annual Conference of Advances in Cardiovascular Therapeutics, Kuala Lumpur, Malaysia, September 1999

1992

Pre-conditioning of mechanically induced premature ventricular beats in the isolated rabbit heart
Presented as a poster communication at the Physiological Society meeting at Cambridge University, September 1992
(PublishedJournal of Physiology 1993; 459, 509P)

Change in serum testosterone and sex hormone binding globulin in male patient post acute myocardial infarction
Presented as a poster communication at the national meeting at of the Association of Clinical Biochemists in Blackpool, June 1992

2012

Wilson S, Levy, T, Swallow R, Sinha M, Talwar S, O’Kane P,
Longitudinal compression of DES during coronary angioplasty: a new epidemic?
Presented as an oral communication at the European Percutaneous Coronary Revascularization Course (Euro PCR), Paris May 2012

Rees P, Fernandez J, Swallow R, Levy, T, Talwar S, O’Kane P,
Safety and efficacy of percutaneous coronary intervention for unprotected left main stem disease in a high volume non-surgical centre
Presented (myself) as an oral communication at the World Congress of Cardiology, Dubai April 2012

2011

Rees P & O’Kane P
Multi-modality imaging in a case of very late stent thrombosis
Presented as an oral communication at the European Percutaneous Coronary Revascularization Course (Euro PCR), Paris May 2011

Fernandez J, McKenzie D, Sinha M, Wells T, Swallow R, Levy, T, Talwar S, O’Kane P,
Safety and efficacy of percutaneous coronary intervention for unprotected left main stem disease in a high volume non-surgical centre
Presented as an oral communication at the European Percutaneous Coronary Revascularization Course (Euro PCR), Paris May 2011

2010

Hobson AR, Fernandez JP, McKenzie D, Jokhi P, Sinha M, Wells T, Swallow R, Levy, T, O’Kane P, Talwar S,
The use of Excimer Laser Coronary Atherectomy (ELCA) for “balloon failure” during percutaneous coronary intervention
Presented as an poster communication at the European Percutaneous Coronary Revascularization Course (Euro PCR), Paris May 2010

Fernandez JP, Hobson AR, McKenzie D, Talwar S, O’Kane P
Excimer Laser Coronary Atherectomy: A Novel Strategy to Aid Management of Stent Underexpansion
Presented as an oral communication at the European Percutaneous Coronary Revascularization Course (Euro PCR), Paris May 2010

Jokhi P, O’Kane P
Excimer laser complication in a very ectatic saphenous vein graft
Presented as an oral communication at the European Percutaneous Coronary Revascularization Course (Euro PCR), Paris May 2010

2012

Wilson S, Hunter G, O’Kane P, Swallow R, Talwar S, Levy, T
Fractional flow reserve assessment for in-stent restenosis: providing the courage to defer target lesion revascularisation in angiographic significant lesions
Presented as an oral communication at the European Percutaneous Coronary Revascularization Course (Euro PCR), Paris May 2012

Rana O, O’Kane P, Swallow R, Talwar S, Levy, T
PCI in the very elderly (>85 years): trends and outcomes
Presented as an poster communication at the European Percutaneous Coronary Revascularization Course (Euro PCR), Paris May 2012

2011

N. Child, G. Hunter, P. O’Kane, J. Paisey, R. Bala, T. Levy
DC cardioversion of atrial fibrillation for patients over 75 years: is it worth the energy?
European Heart Journal P5071

Al Sahli W, Fernandez JP, O’Kane P, Sinha M, Swallow R, Talwar S, Wells T, Levy T.
Mechanisms of drug eluting stent re-stenosis and the importance of intravascular ultrasound in guiding repeat coronary intervention
Presented as an poster communication at the European Percutaneous Coronary Revascularization Course (Euro PCR), Paris May 2011

2010

Perera D, Stables R, Thomas M, Booth J, Pitt M, Blackman D, de Belder A, Redwood S for the BCIS-1 Investigators
Elective intra-aortic balloon counterpulsation during high-risk percutaneous coronary intervention
JAMA 2010; 304(8) 867-874

2008

Lockie TPE, Perera D, O’Kane P, Hartley S, Khan S, Pattinson S, Redwood SR
Do we have the courage to defer coronary intervention? A real-world analysis BCS May 2008
(Published – Heart 94 Supplement II A130)

2006

Blows L, Perera D, O’Kane P, Zbinden R, Evans A, Child A, Redwood S
Comparison between pressure derived and thermodilution derived coronary flow reserve in patients undergoing percutaneous coronary intervention.
AHA Chicago 2006

Blows L, Perera D, O’Kane P, Zbinden R, Evans A, Child A, Redwood S.
Percutaneous intervention leads to a reduction in “minimum” microvascular resistance.
AHA Chicago 2006

J Silberbauer, L Boodhoo, A Arya, P O’Kane, K Kamalvand, G Lloyd, N Patel, N Sulke.
Quality of Life and Symptomatology in Patients with Anti-AF Pacemakers Implanted to Treat Paroxysmal Atrial Fibrillation.
Heart Rhythm May 2006

J Silberbauer, L Boodhoo, A Arya, N Freemantle, D Hildick Smith, S O’Nunain, G Lloyd, K Kamalvand, P O’Kane, N Patel, N Sulke.
The Pacemaker Atrial Fibrillation Study (PAFS): The Effect of Anti-AF Pacing Algorithms in Patients with Paroxysmal Atrial Fibrillation. 
British Cardiac Society April 2006

J Silberbauer, L Boodhoo, A Arya, P O’Kane, K Kamalvand, N Patel, N Sulke.
Quality of Life and Symptomatology in Patients with Anti-AF Pacemakers Implanted to Treat PAF. 
British Cardiac Society April 2006 (Published -Heart. 92 Supplement 2:A85)

J Silberbauer, A Arya, N Freemantle, P O’Kane, K Kamalvand, S O’Nunain, G Lloyd, N Patel, N Sulke.
What Effect Does Right Ventricular Pacing Have in PAF patients? 
European Cardiac Arrhythmia Society April 2006

2005

J Silberbauer, A Arya , P O’Kane, D Hildick-Smith, S O’Nunain, K Kamalvand, N R Patel, N Sulke
Analysis of Early Recurrence of AF (ERAF) in Pacemaker AF Suppression (PAFS) Study.
European Cardiac Arrhythmia Society April 2005

A Arya, J Silberbauer, L Boodhoo, A Mitchell, P O’Kane, D Hildick-Smith, S O’Nunain, K Kamalvand, G Lloyd ,N Patel, N Sulke.
Is All PAF Alike?
European Cardiac Arrhythmia Society April 2005

J Silberbauer, A Arya , P O’Kane, K Kamlavand, D Hildick-Smith, S O’Nunain, N Patel, N Sulke.
Does the Ventricular Rate Stabilisation Algorithm Also Improve Rhythm Control?
European Cardiac Arrhythmia Society April 2005